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6-Mercaptopurine (6-MP) Monohydrate

Product #: TS1957
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Details

l  General Information

Product Name

6-Mercaptopurine (6-MP) Monohydrate

General description

6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. 

Synonym

3,7-dihydropurine-6-thione;hydrate

Purity

≥99.0%(HPLC)

CAS Number

6112-76-1

Formula

C5H6N4OS

Molecular Weight

170.19

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Yellow Solid

Solubility(25°C)

DMSO

≥25mg/ml

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol  Actions

Mercaptopurine is a thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis.

Application

1.Antimetabolites

2.Antimetabolites, Antineoplastic

3.Immunosuppressive Agents

4.Nucleic Acid Synthesis Inhibitors

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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