Product Name

Tolmetin Sodium

General description

Tolmetin is a non-steroidal anti-inflammatory drug of the arylalkanoic acids.

Synonym

sodium; 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate; dihydrate

Purity

≥98.0%(HPLC)

CAS Number

64490-92-2

Formula

C¹⁵H¹⁸NNaO⁵

Molecular Weight

315.301

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

Very slightly soluble

Water

≥50mg/ml

l  Biological Information

Biochem/Physiol  Actions

Tolmetin Sodium is the sodium salt form of tolmetin, an arylalkanoic acid and non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic activities. Although the exact mechanism through which tolmetin exerts its effects has yet to be fully elucidated, this agent appears to inhibit the enzyme prostaglandin synthase. This prevents the formation of prostaglandins from prostaglandin precursors, including the synthesis of the inflammatory prostaglandin E2 (PGE2) from the precursor prostaglandin H2 (PGH2). This prevents prostaglandin-mediated effects, including pain, inflammation and fever.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov