Product Name

Labetalol HCl

General description

Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nive beta-adrenergic receptors, used in the treatment of high blood pressure.  

Synonym

2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide; hydrochloride

Purity

≥98.0%(HPLC)

CAS Number

32780-64-6

Formula

C¹⁹H²⁵ClN²O³

Molecular Weight

364.87

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to off-white Solid

Solubility(25°C)

DMSO

≥50mg/ml

Water

~5mg/ml

l  Biological Information

Biochem/Physiol  Actions

Labetalol Hydrochloride is the hydrochloride form of labetalol, a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects.

Application

1.Antihypertensive Agents

2.Adrenergic alpha-1 Receptor Antagonists

3.Adrenergic beta-Antagonists

4.Sympathomimetics

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov