Product Name

Metoclopramide HCl

General description

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting. 

Synonym

4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide; hydrochloride

Purity

≥98.0%(HPLC)

CAS Number

7232-21-5

Formula

C¹⁴H²³Cl²N³O²

Molecular Weight

336.257

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to off-white Solid

Solubility(25°C)

DMSO

≥50mg/ml

Water

≥50mg/ml

l  Biological Information

Biochem/Physiol  Actions

Metoclopramide Hydrochloride is the hydrochloride salt of the substituted benzamide metoclopramide, a para-aminobenzoic acid (PABA) derivative that is structurally related to procainamide, with gastroprokinetic and antiemetic activities. Metoclopramide binds to dopamine 2 (D2) receptors in the peripheral nervous system (PNS), antagonizing dopamine-mediated relaxation of gastrointestinal smooth muscle and promoting gastroprokinesis; the pyloric sphincter and the duodenal bulb are relaxed, peristalsis of the duodenum and jejunum increase, and gastric emptying and intestinal transit accelerate. This agent may also increase the resting tone of the lower esophagus sphincter (LES), preventing acid reflux. In the central nervous system (CNS), metoclopramide antagonizes D2 dopamine receptors in the chemoreceptive trigger zoe (CTZ) of the medulla, thereby preventing nausea and vomiting.

Application

1.Dopamine D2 Receptor Antagonists

2.Antiemetics

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov