l General Information |
Product Name | Quinacrine 2HCl |
General description | Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor. |
Synonym | 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine; dihydrochloride |
Purity | ≥90.0%(HPLC) | CAS Number | 69-05-6 |
Formula | C23H32Cl3N3O | Molecular Weight | 472.879 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥5mg/ml |
Water | ≥45mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the of antiapoptotic proteins and cytokines while downregulating the of proapoptotic proteins, such as p53. |
Application | 1.Antimalarials 2.Antineoplastic Agents 3.Enzyme Inhibitors 4.Anticestodal Agents 5.Antinematodal Agents |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
