l General Information |
Product Name | Epinastine HCl |
General description | Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. |
Synonym | WAL-801CL HCl; 2,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),3,7,9,11,14,16-heptaen-3-amine; hydrochloride |
Purity | ≥98.0%(HPLC) | CAS Number | 108929-04-0 |
Formula | C16H16ClN3 | Molecular Weight | 285.775 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to off-white solid |
Solubility(25°C) | DMSO | ≥45mg/ml |
Water | ≥45mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Epinastine Hydrochloride is an histamine H1 receptor antagonist without sedative activity. Epinastine hydrochloride blocks the histamine H1 receptor and inhibits the release of histamine from mast cells. This prevents the typical allergic symptoms that are caused by histamine activity on capillaries, skin, mucous membranes, and on gastrointestinal and bronchial smooth muscles. Typical histamine activities include vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscles. Epinastine also has affinity for the histamine H2, 5-HT2, and the alpha-1, alpha-2 adrenergic receptors. |
Application | Histamine H1 Antagonists |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
