Product Name

Mechlorethamine HCl

General description

Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crossing two strands and preventing cell duplication.

Synonym

2-chloro-N-(2-chloroethyl)-N-methylethanamine; hydrochloride

Purity

≥98.0%(T)

CAS Number

55-86-7

Formula

C⁵H¹²Cl³N

Molecular Weight

192.508

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to off-white Solid

Solubility(25°C)

DMSO

≥25mg/ml

Water

≥25mg/ml

l  Biological Information

Biochem/Physiol  Actions

Mechlorethamine Hydrochloride is the hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crossing, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov