Product Name

Bromfenac Sodium

General description

Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has  anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

Synonym

AHR 10282R; sodium;2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate

Purity

≥98.0%(HPLC)

CAS Number

91714-93-1

Formula

C¹⁵H¹¹BrNNaO³

Molecular Weight

356.151

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Faintly yellow to dark Yellow Solid

Solubility(25°C)

DMSO

≥25mg/ml

Water

≥45mg/ml

l  Biological Information

Biochem/Physiol  Actions

Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP).

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov