l General Information |
Product Name | Doxylamine Succinate |
General description | Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects. |
Synonym | butanedioic acid; N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine |
Purity | ≥99.0%(HPLC) | CAS Number | 562-10-7 |
Formula | C21H28N2O5 | Molecular Weight | 388.464 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to off-white Solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Water | ≥50mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
