l General Information |
Product Name | Pilocarpine HCl |
General description | Pilocarpine HCl is a nive muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. |
Synonym | NSC 5746 HCl; (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one; hydrochloride |
Purity | ≥98.0%(HPLC) | CAS Number | 54-71-7 |
Formula | C11H17ClN2O2 | Molecular Weight | 244.719 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or off-white Solid |
Solubility(25°C) | DMSO | ≥35mg/ml |
Water | ≥35mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Pilocarpine Hydrochloride is the hydrochloride salt of a natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent, pilocarpine predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. When applied topically to the eye, this agent stimulates the sphincter pupillae to contract, resulting in miosis; stimulates the ciliary muscle to contract, resulting in spasm of accomodation; and may cause a transitory rise in intraocular pressure followed by a more persistent fall due to opening of the trabecular meshwork and an increase in the outflow of aqueous humor. |
Application | 1.Miotics 2.Muscarinic Agonists |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
