l General Information |
Product Name | Mexiletine HCl |
General description | Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current. |
Synonym | KO1173; 1-(2,6-dimethylphenoxy)propan-2-amine; hydrochloride |
Purity | ≥98.0%(HPLC) | CAS Number | 5370-01-4 |
Formula | C11H18ClNO | Molecular Weight | 215.721 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to off-white Solid |
Solubility(25°C) | DMSO | ≥35mg/ml |
Water | ≥35mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system. |
Application | 1.Anti-Arrhythmia Agents 2.Voltage-Gated Sodium Channel Blockers |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
