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Amoxapine

Product #: TS1838
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Details

l  General Information

Product Name

Amoxapine

General description

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.

Synonym

CL 67772; 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine

Purity

≥98.0%(HPLC)

CAS Number

14028-44-5

Formula

C17H16ClN3O

Molecular Weight

313.785

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

Slightly soluble

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol  Actions

Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.

Application

1.Antidepressive Agents, Tricyclic

2.Dopamine Antagonists

3.Adrenergic Uptake Inhibitors

4.Neurotransmitter Uptake Inhibitors

5.Serotonin Uptake Inhibitors

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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