l General Information |
Product Name | Isosorbide |
General description | Isosorbide
is a heterocyclic compound that is derived from glucose, used as a diuretic. |
Synonym | (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol |
Purity | ≥97.0%(HPLC) | CAS Number | 652-67-5 |
Formula | C6H10O4 | Molecular Weight | 146.142 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to yellow to pale brown solid |
Solubility(25°C) | DMSO | ≥15mg/ml |
Ethanol | ≥15mg/ml |
Water | ≥15mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Isosorbide is an organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. |
Application | Diuretics, Osmotic |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
