l General Information |
Product Name | Penciclovir |
General description | Penciclovir is a purine acyclic nucleoside analogue with potent antiviral activity. |
Synonym | BRL-39123, VSA 671; 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1H-purin-6-one |
Purity | ≥99.0%(HPLC) | CAS Number | 39809-25-1 |
Formula | C10H15N5O3 | Molecular Weight | 253.262 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to off-white Solid |
Solubility(25°C) | DMSO | ≥25mg/ml |
Ethanol | Insoluble |
Water | Slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Penciclovir is a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
