Product Name

Ceftriaxone Sodium Trihydrate

General description

Ceftriaxone sodium trihydrate is a third-generation cephalosporin antibiotic.

Purity

≥98.0%(HPLC)

CAS Number

104376-79-6

Formula

C¹⁸H¹⁶N⁸Na²O⁷RS³

Molecular Weight

661.6

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Light Yellow Solid

Solubility(25°C)

DMSO

Slightly soluble

Ethanol

Insolube

Water

≥50mg/ml

l  Biological Information

Biochem/Physiol  Actions

Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-age of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov