Product Name

Clodronate Disodium

General description

Clodronate Disodium, a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption.

Synonym

disodium; [dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate

Purity

≥99.0%(HPLC)

CAS Number

22560-50-5

Formula

CH²Cl²Na²O⁶P²

Molecular Weight

288.848

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to off-white Solid

Solubility(25°C)

DMSO

Insoluble

Ethanol

Insoluble

Water

≥50mg/ml

l  Biological Information

Biochem/Physiol  Actions

Clodronate Disodium is the disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov