Product Name

2,4-Diamino-6-hydroxypyrimidine

General description

2,4-Diamino-6-hydroxypyrimidine is a specific inhibitor for GTP cyclohydrolase I, the rate-limiting enzyme in de novo pterin synthesis.

Synonym

DAHP; 2,4-diamino-1H-pyrimidin-6-one

Purity

≥98.0%(HPLC)

CAS Number

56-06-4

Formula

C⁴H⁶N⁴O

Molecular Weight

126.119

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to off-white Solid

Solubility(25°C)

DMSO

≥15mg/mL

Ethanol

Insoluble

Water

~5mg/mL

l  Biological Information

Biochem/Physiol  Actions

2, 4-Diamino-6-hydroxypyrimidine (DAHP) is a selective inhibitor of GTP cyclohydrolase I (GTPCH) that restricts the de novo synthesis of tetrahydrobiopterin (BH4) or the BH4 precursor in vascular smooth muscle cells (VSMC). (PMID:12883322). 2, 4-Diamino-6-hydroxypyrimidine also inhibits nitric oxide (NO) in both Interferon-gamma (IFN-gamma) and antigen (Ag)/IgE (Ag/IgE) systems, increasing Mast cells (MC) degranulation.(PMID: 14514683). Sepiapterin, a precursor to tetrahydrobiopterin in the salvage pathway, completely reverses the effect of 2, 4-diamino-6-hydroxypyrimidine on neuronal NO-synthase (nNOS) ubiquitylation.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov