l General Information |
Product Name | O6-Benzylguanine |
General description | O6-Benzylguanine is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. |
Synonym | O6-BG; 6-phenylmethoxy-7H-purin-2-amine |
Purity | ≥98.0%(HPLC) | CAS Number | 19916-73-5 |
Formula | C12H11N5O | Molecular Weight | 241.254 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to White w/ Yellow solid |
Solubility(25°C) | DMSO | ≥35mg/mL |
Ethanol | ≥5mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | O6-Benzylguanine is a guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. |
Application | 1.Antineoplastic Agents 2.Enzyme Inhibitors |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
