Product Name

Entacapone

General description

Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM.

Synonym

OR-611; (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide

Purity

≥98.0%(HPLC)

CAS Number

130929-57-6

Formula

C¹⁴H¹⁵N³O⁵

Molecular Weight

305.29

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Light Brown Solid

Solubility(25°C)

DMSO

≥50mg/mL

Ethanol

Slightly soluble

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

Entacapone is a nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), which catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including dihydroxyphenylalanine (DOPA), catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents the metabolism and inactivation of adjunct drugs, thereby increasing the bioavailability of these compounds by facilitating their passage across the blood-brain barrier.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov