l General Information |
Product Name | Tripelennamine HCl |
General description | Tripelennamine HCl is a widely used H1 antagonist, inhibiting PhIP glucuronidation with IC50 of 30 μM. |
Synonym | Pyribenzamine HCl; N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine;hydrochloride |
Purity | ≥98.0%(HPLC) | CAS Number | 154-69-8 |
Formula | C16H22ClN3 | Molecular Weight | 291.823 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | Slightly soluble |
Ethanol | Slightly soluble |
Water | ≥45mg/mL |
l Biological Information |
Biochem/Physiol
Actions | Tripelennamine Hydrochloride is the hydrochloride salt form of tripelennamine, an ethylenediamine derivative with an antihistaminergic property. Tripelennamine hydrochloride competitively blocks central and peripheral histamine H1 receptors, thereby limiting histamine's effects, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic activity. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
