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Amikacin hydrate

Product #: TS1275
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Details

l  General Information

Product Name

Amikacin hydrate

General description

Amikacin hydrate is an aminoglycoside antibiotic used to treat different types of bacterial infections.

Purity

≥98.0%(HPLC)

CAS Number

37517-28-5

Formula

C22H43N5O13

Molecular Weight

585.6

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to off-white Solid

Solubility(25°C)

DMSO

Insoluble

Ethanol

Insoluble

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol  Actions

Amikacin is a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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