l General Information |
Product Name | Dexmedetomidine |
General description | Dexmedetomidine is a sedative medication used by intensive care units and anesthetists. |
Synonym | 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole |
Purity | ≥98.0%(HPLC) | CAS Number | 113775-47-6 |
Formula | C13H16N2 | Molecular Weight | 200.285 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥35mg/mL |
Ethanol | ≥35mg/mL |
Water | ≥35mg/mL |
l Biological Information |
Biochem/Physiol
Actions | Dexmedetomidine is an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative properties. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
