Product Name

PF-477736

General description

PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2. Phase 1.

Synonym

PF-736; PF-00477736

Purity

≥98.0%(HPLC)

CAS Number

952021-60-2

Formula

C²²H²⁵N⁷O²

Molecular Weight

419.489

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Yellow Solid

Solubility(25°C)

DMSO

≥50mg/mL

Ethanol

Insoluble

Water

Insoluble

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov