Product Name

5-Aminolevulinic acid HCl

General description

5-Aminolevulinic Acid HCl is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.

Synonym

5-amino-4-oxopentanoic acid;hydrochloride

Purity

≥97.0%(HPLC)

CAS Number

5451-09-2

Formula

C⁵H¹⁰ClNO³

Molecular Weight

167.589

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Off-White Solid

Solubility(25°C)

DMSO

≥25mg/mL

Ethanol

~5mg/mL

Water

≥25mg/mL

l  Biological Information

Biochem/Physiol  Actions

Aminolevulinic Acid Hydrochloride is the hydrochloride salt form of aminolevulinic acid, an aminoketone, used for local photosensitizing therapy. Aminolevulinic acid (ALA) is a metabolic pro-drug that is converted into the photosensitizer protoporphyrin IX (PpIX), which accumulates intracellularly. Upon exposure to light of appropriate wavelength (red, or blue), PpIX catalyzes oxygen to singlet oxygen, an intracellular toxin, which can further react to form superoxide and hydroxyl radicals. This leads to cellular cytotoxic effects.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov