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Phenytoin

Product #: TS1044
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Details

l  General Information

Product Name

Phenytoin

General description

Phenytoin is an inactive voltage-gated sodium channel stabilizer.

Synonym

Diphenylhydantoin; 5,5-diphenylimidazolidine-2,4-dione

Purity

≥98.0%(HPLC)

CAS Number

57-41-0

Formula

C15H12N2O2

Molecular Weight

252.273

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Off White Solid

Solubility(25°C)

DMSO

≥45mg/mL

Ethanol

≥5mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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