l General Information |
Product Name | Phenytoin |
General description | Phenytoin is an inactive voltage-gated sodium channel stabilizer. |
Synonym | Diphenylhydantoin; 5,5-diphenylimidazolidine-2,4-dione |
Purity | ≥98.0%(HPLC) | CAS Number | 57-41-0 |
Formula | C15H12N2O2 | Molecular Weight | 252.273 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Off White Solid |
Solubility(25°C) | DMSO | ≥45mg/mL |
Ethanol | ≥5mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |