l General Information |
Product Name | Phenoxybenzamine HCl |
General description | Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM. |
Synonym | NSC 37448, NCI-c01661; N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine;hydrochloride |
Purity | ≥98.0%(HPLC) | CAS Number | 63-92-3 |
Formula | C18H23Cl2NO | Molecular Weight | 340.288 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Off White solid |
Solubility(25°C) | DMSO | ≥50mg/mL |
Ethanol | ≥50mg/mL |
Water | ≥5mg/mL |
l Biological Information |
Biochem/Physiol
Actions | Phenoxybenzamine Hydrochloride is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
