l General Information |
Product Name | Domperidone |
General description | Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting. |
Synonym | 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one |
Purity | ≥98.0%(HPLC) | CAS Number | 57808-66-9 |
Formula | C22H24ClN5O2 | Molecular Weight | 425.917 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Off White Solid |
Solubility(25°C) | DMSO | ≥35mg/mL |
Ethanol | Slightly soluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Domperidone is a peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
