l General Information |
Product Name | Amantadine HCl |
General description | Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus. |
Synonym | 1-adamantanamine HCl; adamantan-1-amine; hydrochloride |
Purity | ≥97.0%(HPLC) | CAS Number | 665-66-7 |
Formula | C10H18ClN | Molecular Weight | 187.711 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Off White Solid |
Solubility(25°C) | DMSO | ≥25mg/mL |
Ethanol | ≥25mg/mL |
Water | ≥25mg/mL |
l Biological Information |
Biochem/Physiol
Actions | Amantadine Hydrochloride is the hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
