l General Information |
Product Name | Ambrisentan |
General description | Ambrisentan is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH). |
Synonym | LU-208075,BSF-208075; (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid |
Purity | ≥98.0%(HPLC) | CAS Number | 177036-94-1 |
Formula | C22H22N2O4 | Molecular Weight | 378.428 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Beige Powder |
Solubility(25°C) | DMSO | ≥50mg/mL |
Ethanol | ≥15mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Ambrisentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy, but has yet to be implicated in cases of clinically apparent acute liver injury. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
