l General Information |
Product Name | Dexmedetomidine HCl |
General description | Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation. |
Synonym | 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole; hydrochloride |
Purity | ≥98.0%(HPLC) | CAS Number | 145108-58-3 |
Formula | C13H17ClN2 | Molecular Weight | 236.743 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥35mg/mL |
Ethanol | ≥35mg/mL |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Dexmedetomidine Hydrochloride is the hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
