l General Information |
Product Name | Pyrimethamine |
General description | Pyrimethamine is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug. |
Synonym | 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |
Purity | ≥98.0%(HPLC) | CAS Number | 58-14-0 |
Formula | C12H13ClN4 | Molecular Weight | 248.714 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Off-White Solid |
Solubility(25°C) | DMSO | ≥5mg/mL |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | Pyrimethamine is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
