l General Information |
Product Name | D-Cycloserine |
General description | D-cycloserine is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis. |
Synonym | RO-1-9213; (4R)-4-amino-1,2-oxazolidin-3-one |
Purity | ≥98.0%(HPLC) | CAS Number | 68-41-7 |
Formula | C3H6N2O2 | Molecular Weight | 102.093 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Pale Cream or Pale Yellow Solid |
Solubility(25°C) | DMSO | Insoluble |
Ethanol | Insoluble |
Water | ≥15mg/mL |
l Biological Information |
Biochem/Physiol
Actions | Cycloserine is an analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
