l General Information |
Product Name | Primidone |
General description | Primidone is an anticonvulsant of the pyrimidinedione class. |
Synonym | NCI-C56360; 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione |
Purity | ≥98.0%(HPLC) | CAS Number | 125-33-7 |
Formula | C12H14N2O2 | Molecular Weight | 218.256 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost White Solid |
Solubility(25°C) | DMSO | ≥25mg/mL |
Ethanol | Very slightly soluble |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Primidone is an analog of phenobarbital with antiepileptic property. Although the mechanism of action has not been fully elucidated, primidone probably exerts its actions, in a manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A receptor/chloride ionophore complex, which leads to prolonged and increased frequency of opening of the chloride channel within the receptor complex. This results in an alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization and prevention of partial and tonic-clonic seizures. In addition, this agent is partially metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute to its anti-seizure properties. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
