l General Information |
Product Name | Bifonazole |
General description | Bifonazole is a substituted imidazole antifungal agent. |
Synonym | Bay h 4502; 1-[phenyl-(4-phenylphenyl)methyl]imidazole |
Purity | ≥98.0%(HPLC) | CAS Number | 60628-96-8 |
Formula | C22H18N2 | Molecular Weight | 310.4 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or almost White Solid |
Solubility(25°C) | DMSO | ≥45mg/mL |
Ethanol | ≥5mg/mL |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Bifonazole is only found in individuals that have used or taken this drug. It is an azole antifungal drug. [Wikipedia]Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes. It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
