l General Information |
Product Name | Nedaplatin |
General description | Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM. |
Synonym | azanide; 2-hydroxyacetic acid; platinum(2+) |
Purity | ≥98.0%(HPLC) | CAS Number | 95734-82-0 |
Formula | C2H8N2O3Pt | Molecular Weight | 303.181 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to Yellow or Yellow-Green or Green Solid |
Solubility(25°C) | DMSO | Insoluble |
Ethanol | Insoluble |
Water | Slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Nedaplatin is a second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-s, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
