Product Name

Thiotepa

General description

Thiotepa(Thioplex) is an alkylating agent used to treat cancer.

Synonym

Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide; tris(aziridin-1-yl)-sulfanylidene-λ5-phosphane

Purity

≥97.0%(HPLC)

CAS Number

52-24-4

Formula

C⁶H¹²N³PS

Molecular Weight

189.217

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or off-white Solid

Solubility(25°C)

DMSO

≥45mg/mL

Ethanol

≥45mg/mL

Water

≥45mg/mL

l  Biological Information

Biochem/Physiol  Actions

Thiotepa is a polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crossing of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov