l General Information |
Product Name | Mitotane |
General description | Mitotane, is an antineoplastic medication used in the treatment of adrenocortical carcinoma. |
Synonym | NCI-C04933; 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene |
Purity | ≥98.0%(HPLC) | CAS Number | 53-19-0 |
Formula | C14H10Cl4 | Molecular Weight | 320.034 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥45mg/mL |
Ethanol | ≥45mg/mL |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Mitotane is a synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
