l General Information |
Product Name | Zalcitabine |
General description | Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
Synonym | NSC 606170; Ro 24-2027/000; 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
Purity | ≥98.0%(HPLC) | CAS Number | 7481-89-2 |
Formula | C9H13N3O3 | Molecular Weight | 211.22 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or off-white Solid |
Solubility(25°C) | DMSO | ≥25mg/ml |
Ethanol | Insoluble |
Water | ≥25mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Zalcitabine is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
