l General Information |
Product Name | Fomepizole |
General description | Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. |
Synonym | 4-methylpyrazole, Antizol, Antizol-Vet; 4-methyl-1H-pyrazole |
Purity | ≥98.0%(HPLC) | CAS Number | 7554-65-6 |
Formula | C4H6N2 | Molecular Weight | 82.106 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Liquid |
Solubility(25°C) | DMSO | ≥50mg/mL. |
Ethanol | ≥50mg/mL. |
l Biological Information |
Biochem/Physiol
Actions | Fomepizole is a pyrazole with competitive alcohol dehydrogenase inhibitor activity. Fomepizole prevents the metabolism of ethylene glycol and methanol by alcohol dehydrogenase, thereby inhibiting the formation of their toxic metabolites, glycolate and oxalate (from ethylene glycol), and formic acid (from methanol). Fomepizole is indicated for use as an antidote in ethylene glycol and methanol poisoning. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
