Product Name

Progesterone

General description

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM An agonist of the membrane progesterone receptors(mPRs) An antagonist of the σ1 receptor.

Synonym

1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea

Purity

≥98.0%(HPLC)

CAS Number

57-83-0

Formula

C²¹H³⁰O²

Molecular Weight

348.421

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or off-white Solid

Solubility(25°C)

DMSO

≥5mg/ml

Ethanol

≥45mg/ml

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol  Actions

Therapeutic Progesterone is a synthetic form of the endogenous hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov