l General Information |
Product Name | Aminophylline |
General description | Aminophylline is a competitive nive phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nive adenosine receptor antagonist. |
Synonym | Phyllocontin; 1,3-dimethyl-7H-purine-2,6-dione;ethane-1,2-diamine |
Purity | ≥98.0%(HPLC) | CAS Number | 317-34-0 |
Formula | C16H24N10O4 | Molecular Weight | 420.434 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or Slightly Yellow Solid |
Solubility(25°C) | DMSO | ≥35mg/ml |
Ethanol | Very slightly soluble |
Water | ≥45mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Aminophylline is a methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
