l General Information |
Product Name | Aminoglutethimide |
General description | Aminoglutethimide is an aromatase inhibitor with IC50 of 10 μM. |
Synonym | BA-16038, NSC-330915; 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione |
Purity | ≥98.0%(HPLC) | CAS Number | 125-84-8 |
Formula | C13H16N2O2 | Molecular Weight | 232.283 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or slightly yellow solid |
Solubility(25°C) | DMSO | ≥5mg/ml |
Ethanol | Slightly soluble |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Aminoglutethimide is a synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties. Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens. Aminoglutethimide does not suppress ovarian estrogen production. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
