l General Information |
Product Name | Metolazone |
General description | Metolazone is a diuretic that primarily used to treat congestive heart failure and high blood pressure. |
Synonym | SR 720-22;
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide |
Purity | ≥98.0%(HPLC) | CAS Number | 17560-51-9 |
Formula | C16H16ClN3O3S | Molecular Weight | 365.832 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or off-white solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Ethanol | ≥5mg/ml |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Metolazone is a long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT) and inhibits the sodium-chloride symporter, thereby preventing sodium and chloride reabsorption and excretion of water. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
