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Pyridostigmine Bromide

Product #: TS0662
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l  General Information

Product Name

Pyridostigmine Bromide

General description

Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

Synonym

(1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate;bromide

Purity

≥98.0%(HPLC)

CAS Number

101-26-8

Formula

C9H13BrN2O2

Molecular Weight

261.119

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White or off-white solid

Solubility(25°C)

DMSO

≥45mg/ml

Ethanol

≥45mg/ml

Water

≥45mg/ml

l  Biological Information

Biochem/Physiol  Actions

Pyridostigmine Bromide is the bromide salt form of pyridostigmine, a quaternary ammonium carbamate derivative and a acetylcholinesterase inhibitor. Pyridostigmine bromide binds reversibly to acetylcholinesterase active sites in the peripheral nervous system, thereby preventing the breakdown of acetylcholine. This leads to an accumulation of acetylcholine at cholinergic synapses and facilitates transmission of impulses across the neuromuscular junction. Mediated through muscarinic receptors, this agent increases contraction of bronchial and intestinal smooth muscle and the exocrine glands secretions, while it causes paralysis of the skeletal muscles mediated through nicotinic receptors. In addition, pyridostigmine is used as a reversible blocking agent to prevent organophosphates from binding to the acetylcholinesterase receptors and thereby protect the nervous system from the effects of nerve agents such as Soman.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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