l General Information |
Product Name | Irbesartan |
General description | Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM. |
Synonym | BMS-186295, SR-47436; 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one |
Purity | ≥98.0%(HPLC) | CAS Number | 138402-11-6 |
Formula | C25H28N6O | Molecular Weight | 428.54 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or off-white Solid |
Solubility(25°C) | DMSO | ≥45mg/ml |
Ethanol | Very slight soluble |
Water | Very slight soluble |
l Biological Information |
Biochem/Physiol
Actions | Irbesartan is a nonpeptide angiotensin II antagonist with antihypertensive activity. Irbesartan selectively and competitively blocks the binding of angiotensin II to the angiotensin I receptor. Angiotensin II stimulates aldosterone synthesis and secretion by adrenal cortex, which decreases the excretion of sodium
and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
