l General Information |
Product Name | Perindopril Erbumine |
General description | Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM. |
Purity | ≥98.0%(HPLC) | CAS Number | 107133-36-8 |
Formula | C23H43N3O5 | Molecular Weight | 441.613 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White or off-white Solid |
Solubility(25°C) | DMSO | Insoluble |
Ethanol | ≥45mg/ml |
Water | ≥45mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Perindopril Erbumine is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
