l General Information |
Product Name | Zileuton |
General description | Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma. |
Synonym | A-64077; 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea |
Purity | ≥98.0%(HPLC) | CAS Number | 111406-87-2 |
Formula | C11H12N2O2S | Molecular Weight | 236.289 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥25mg/ml |
Ethanol | ≥25mg/ml |
Water | Very slight soluble |
l Biological Information |
Biochem/Physiol
Actions | Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
