Product Name

Pelitinib

General description

Pelitinib is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM.

Synonym

EKB-569; (E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

Purity

≥98.0%(HPLC)

CAS Number

257933-82-7

Formula

C²⁴H²³ClFN⁵O²

Molecular Weight

467.929

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

~5mg/ml

Ethanol

Insoluble

Water

Very slight soluble

l  Biological Information

Biochem/Physiol  Actions

Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov