l General Information |
Product Name | Ivermectin |
General description | Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a
broad-spectrum antiparasitic drug. |
Synonym | MK933 |
Purity | Ivermectin B1A: ≥90.0%(HPLC) Ivermectin B1B: ≤5.0%(HPLC) Ivermectin B1A+ Ivermectin B1B: ≥95.0%(HPLC) | CAS Number | 70288-86-7 |
Formula | C48H74O14 | Molecular Weight | 875.106 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to white or light beige solid |
Solubility(25°C) | DMSO | ≥45mg/ml |
Ethanol | ≥5mg/ml |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Ivermectin is a macrocyclic lactone derived from Streptomyces avermitilis with antiparasitic activity. Ivermectin exerts its anthelmintic effect via activating glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells. Distinct
from the channel opening induced by endogenous glutamate transmitter, ivermectin-activated channels open very slowly but essentially irreversibly. As a result, neurons or muscle cells remain at either hyperpolarisation or depolarization state, thereby resulting in paralysis and death of the parasites. Ivermectin does not readily pass the mammal blood-brain barrier to the central nervous system where glutamate-gated chloride channels locate, hence the hosts are relatively resistant to the effects of this agent. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
