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Dutasteride

Product #: TS0530
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Details

l  General Information

Product Name

Dutasteride

General description

Dutasteride is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).

Synonym

GI198745, GG-745

Purity

≥98.0%(HPLC)

CAS Number

164656-23-9

Formula

C27H30F6N2O2

Molecular Weight

528.539

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Pale Yellow Solid

Solubility(25°C)

DMSO

≥50mg/ml

Ethanol

≥15mg/ml

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol  Actions

Dutasteride is a synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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